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Tomohiro Kaku Selected Research

orteronel

11/2013Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys.
4/2012Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys.
11/2011Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer.

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Tomohiro Kaku Research Topics

Disease

6Prostatic Neoplasms (Prostate Cancer)
03/2013 - 08/2004
4Neoplasms (Cancer)
11/2013 - 04/2012
1Disease Progression
04/2012
1Transient Ischemic Attack
08/2002
1Ischemia
08/2002
1Brain Ischemia (Cerebral Ischemia)
08/2002

Drug/Important Bio-Agent (IBA)

3orteronelIBA
11/2013 - 11/2011
3AndrogensIBA
03/2013 - 08/2004
2Androgen Receptors (Androgen Receptor)IBA
01/2013 - 04/2012
2bicalutamide (Casodex)FDA LinkGeneric
01/2013 - 04/2012
2Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
04/2012 - 11/2011
1Hormones (Hormone)IBA
11/2013
1Estradiol (Delestrogen)FDA LinkGeneric
11/2013
1Estrogens (Estrogen)FDA Link
11/2013
1AmidesIBA
01/2013
1SteroidsIBA
04/2012
1Testosterone (Sustanon)FDA Link
04/2012
1Dehydroepiandrosterone (DHEA)IBA
04/2012
1Hydrocortisone (Cortisol)FDA LinkGeneric
04/2012
1EnzymesIBA
04/2012
17-nitroindazoleIBA
08/2002
1Nitric Oxide Synthase (NO Synthase)IBA
08/2002
1Nitric Oxide (Nitrogen Monoxide)FDA Link
08/2002
1Glutamic Acid (Glutamate)FDA Link
08/2002
1N(G)-iminoethylornithineIBA
08/2002

Therapy/Procedure

4Castration
01/2013 - 11/2011
1Therapeutics
04/2012